Performance on MMSE sub-items and education level in presenilin-1 mutation carriers without dementia
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چکیده
منابع مشابه
Dual memory task impairment in E280A presenilin-1 mutation carriers.
Patients with sporadic Alzheimer's disease (AD) are impaired in their ability to perform two tasks concurrently compared to healthy younger and older adults, despite being able to successfully perform the tasks on their own reasonably well. Dual task impairments have also been found in those individuals with an E280A presenilin-1 genetic mutation but who do not yet meet the criteria for AD. The...
متن کاملCortical atrophy in presymptomatic Alzheimer's disease presenilin 1 mutation carriers.
BACKGROUND Sporadic late-onset Alzheimer's disease (AD) dementia has been associated with a 'signature' of cortical atrophy in paralimbic and heteromodal association regions measured with MRI. OBJECTIVE To investigate whether a similar pattern of cortical atrophy is present in presymptomatic presenilin 1 E280A mutation carriers an average of 6 years before clinical symptom onset. METHODS 40...
متن کاملAmyloid deposition begins in the striatum of presenilin-1 mutation carriers from two unrelated pedigrees.
The amyloid cascade hypothesis suggests that the aggregation and deposition of amyloid-beta protein is an initiating event in Alzheimer's disease (AD). Using amyloid imaging technology, such as the positron emission tomography (PET) agent Pittsburgh compound-B (PiB), it is possible to explore the natural history of preclinical amyloid deposition in people at high risk for AD. With this goal in ...
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تعداد 20 رأس میش نژاد نائینی 6+-24 ماهه، با میانگین وزن 2/3-+40 کیلوگرم، همراه با 20 رأس بره های آنها در قالب طرح کاملا تصادفی اثر بتائین و مکمل سولفات بر خصوصیات شیر و پشم و عملکرد بره ها بررسی شد. میش ها بطور تصادفی در چهار تیمار قرار گرفتند. تیمارها عبارت بودند از: 1-گروه شاهد 2-بتائین (05/0 درصد ماده خشک) 3-سولفات (24/0 سولفور درصد ماده خشک 4-بتائین هرماه با سولفات. جیره غذائی طبق nrc با مح...
15 صفحه اولPresenilin 1 mutation in an african american family presenting with atypical Alzheimer dementia.
BACKGROUND Alzheimer disease (AD) is characterized by memory and visuospatial deficits with relative sparing of personality. Mutations in 3 genes (presenilin 1 and 2 and amyloid precursor protein) are associated with presenile AD. Presenilin 1 gene mutations have not been described in African Americans. METHODS We studied an African American family with autosomal dominant rapidly progressive ...
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ژورنال
عنوان ژورنال: International Psychogeriatrics
سال: 2006
ISSN: 1041-6102,1741-203X
DOI: 10.1017/s1041610206003772